The changes of adiponectin,high-sensitivity C-reactive protein and intima media thickness in the elderly with type 2 diabetes mellitus and cerebral infarction

Objective To investigate the changes of adiponectin,high-sensitivity C-reactive protein(hs-CRP) and intima media thickness(IMT) in the elderly with type 2 diabetes mellitus(T2DM) and cerebral infarction.Methods Blood glucose(BG),blood fat,liver and renal function,glycosylated hemoglobin(HbA1c) and hs-CRP were examined in 30 normal controls(group A),30 T2DM patients without cerebral infarction(group B) and 33 T2DM patients with cerebral infarction(group C).Serum adiponectin(APN) was determined by ELISA.The carotid atherosclerosis plaque and IMT were detected by Dopplar ultrasound examination.The differences among three groups were analyzed.Results Compared to group A,hs-CRP and IMT were higher in groups of B and C(P0.05).Serum APN level of three groups was in an order of group A group B group C(P0.05).Serum APN level was negatively correlated to hs-CRP and IMT(r=-0.528 and r=-0.585)(P0.05).Conclusion The severity of carotid atherosclerosis induced by inflammatory reaction is more in T2DM patients with cerebral infarction than that in those without.Combined detection of adiponectin,hs-CRP and IMT is helpful in the diagnosis and evaluation of prognosis in T2DM patients with cerebral infarction.