Significance of Serum Homocysteine,Adiponectin,High-sensitivity C-reactive Protein Levels and Carotid Intima-media Thickness in Elderly Type 2 Diabetes Patients with Cerebral Infarction

Objective:To observe the significance of serum homocysteine(Hcy),adiponectin(APN),high-sensitivity C-reactive protein(hs-CRP) levels and carotid intima-media thickness(IMT) in elderly type 2 diabetes patients with cerebral infarction.Methods:218 patients with type 2 diabetes admitted in our hospital from May 2008 to May 2012 were selected and randomly divided into diabetes combined with cerebral infarction group(DM with CI group,105 cases) and DM group(113 cases).30 healthy persons during the same period were selected as healthy control group.The serum levels of Hcy,APN and hs-CRP as well as IMT were observed and compared among three groups.Results:The serum levels of Hcy,hs-CRP and IMT in DM with CI group and DM group were increased significantly compared with the control group(P0.01),which were obviously higher in DM with CI group than those in DM group(P0.01);while the serum levels of APN in DM with CI group and DM group were both significantly lower than those in the control group(P0.01),which were obviously lower than those in the DM group(P0.01).As the severity of IMT increased,the serum levels of Hcy and hs-CRP decreased(P0.01),while,the levels of APN decreased significantly(P0.01).Conclusion:Type 2 diabetes patients with cerebral infarction have more serious macrovascular complication than those only with diabetes,the carotid IMT was positively correlated with serum levels of Hcy and hs-CRP and negatively correlated with serum APN level.