The relationship among serum adiponectin,hs-CRP and IMT of carotid in type 2 diabetic patients

Objective:To investigate the relationship among serum adiponectin,hs-CRP and IMT of carotid in type 2 diabetic patients.Methods:287 cases of type 2 diabetes included 148 males and 139 females.We collected the related clinical data,measured the fasting serum adiponectin by ELISA,by immuno-turbidimetry and measured the level of hs-CRP by finally,type 2 diabetic subjects were divided into two groups depending on the carotid ultrasound results: IMT normal group and IMT thickening or plaque group.The relationship among serum adiponectin,hs-CRP and IMT was analyzed.Results: ① In categorical analysis,the mean level of serum adiponectin and HDL-C in IMT thickening or plaque group was significantly lower than that in the other group;② In pearson correlation analysis,APN as the dependent variable and the index for the independent variable,the results showed that BMI,WHR,TG,hs-CRP and APN were negatively correlated;HDL-C and APN levels were positively correlated;③ In multiple stepwise regression analysis,serum adiponectin,hs-CRP and HDL-C were related to the formation of diabetic IMT.Conclusion:APN may be the protective factor to atherosclerosis of diabetic patients.