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2011•Chinese Journal of Natural MedicinesRequires access

Two New Triterpenoid Saponins from the Roots of Gypsophila paniculata with Potent α-Glucosidase Inhibition Activity

Jian Luo

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Abstract

AIM:To investigate chemical constituents of Gypsophila paniculata.METHODS:The compounds were isolated by silica gel,Sephadex LH-20,Rp-C18 column chromatography and preparative liquid chromatography.Their structures were elucidated by ESI-MS,NMR techniques (1H,13C,HMQC,HMBC,TOCSY) and acid hydrolysis.Moreover their α-glucosidase inhibition activity was evaluated compared with that of their aglycone.RESULTS:Two triterpenoid saponins,caryophyllacosides A (1) and B (2),were isolated from the roots of Gypsophila paniculata,without having recourse to chemical degradation or modification.Both of them were found to have potent α-glucosidase inhibitiory activity.CONCLUSION:The two triterpenoid saponins are new boactive compounds.

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What this paper is about

AIM:To investigate chemical constituents of Gypsophila paniculata.METHODS:The compounds were isolated by silica gel,Sephadex LH-20,Rp-C18 column chromatography and preparative liquid chromatography.Their structures were elucidated by ESI-MS,NMR techniques (1H,13C,HMQC,HMBC,TOCSY) and acid hydrolysis.Moreover their α-glucosidase inhibition activity was evaluated compared with that of their aglycone.RESULTS:Two triterpenoid saponins,caryophyllacosides A (1) and B (2),were isolated from the roots of Gypsophila paniculata,without having recourse to chemical degradation or modification.Both of them were found to have potent α-glucosidase inhibitiory activity.CONCLUSION:The two triterpenoid saponins are new boactive compounds.

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Available abstract

AIM:To investigate chemical constituents of Gypsophila paniculata.METHODS:The compounds were isolated by silica gel,Sephadex LH-20,Rp-C18 column chromatography and preparative liquid chromatography.Their structures were elucidated by ESI-MS,NMR techniques (1H,13C,HMQC,HMBC,TOCSY) and acid hydrolysis.Moreover their α-glucosidase inhibition activity was evaluated compared with that of their aglycone.RESULTS:Two triterpenoid saponins,caryophyllacosides A (1) and B (2),were isolated from the roots of Gypsophila paniculata,without having recourse to chemical degradation or modification.Both of them were found to have potent α-glucosidase inhibitiory activity.CONCLUSION:The two triterpenoid saponins are new boactive compounds.

Key concepts: Chemistry, Aglycone, Column chromatography, Sephadex, Triterpenoid saponin, Triterpenoid, Chemical constituents, Chromatography

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Two New Triterpenoid Saponins from the Roots of Gypsophila paniculata with Potent α-Glucosidase Inhibition Activity — Research Paper | ScholarLens