New Triterpenoid Saponins from the Roots of Gypsophila paniculata L.

Abstract The seven new triterpenoid saponins 1–7 were isolated from the roots of Gypsophila paniculata L. Their structures were established by 1D‐ and 2D‐NMR techniques, HR‐MS, and acid hydrolysis. The isolated compounds include 3,28‐O‐bidesmosides with or without a 4‐methoxycinnamoyl group (see 1 vs. 2 and 3), and 3‐O‐monoglucosides 4–7. All isolated saponins 1–7 and their aglycones were evaluated for their α‐glucosidase inhibition activity. Compound 1 showed inhibitory activity against yeast α‐glucosidase with an IC50 value of 100.9±3.3 μM, whereas compounds 2–7 were inactive.