Two New Triterpenoid Saponins from the Roots ofGypsophila paniculata with Potent α-Glucosidase Inhibition Activity

Abstract Aim To investigate chemical constituents of Gypsophila paniculata . Methods The compounds were isolated by silica gel, Sephadex LH-20, Rp-C 18 column chromatography and preparative liquid chromatography. Their structures were elucidated by ESI-MS, NMR techniques ( 1 H, 13 C, HMQC, HMBC, TOCSY) and acid hydrolysis. Moreover their α-glucosidase inhibition activity was evaluated compared with that of their aglycone. Results Two triterpenoid saponins, caryophyllacosides A ( 1 ) and B ( 2 ), were isolated from the roots of Gypsophila paniculata , without having recourse to chemical degradation or modification. Both of them were found to have potent α-glucosidase inhibitiory activity. Conclusion The two triterpenoid saponins are new boactive compounds.