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2010•Chinese Preventive MedicineRequires access

The early diagnostic value of combined determination of serum Cys C and urine microprotein in diabetic nephropathy

Fenge Li

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Abstract

Objective To explore the early diagnostic value of combined determination of serum Cys C,urine α1-MG and β2-MG in diabetic nephropathy.Methods Serum Cys C,urinary α1-MG and β2-MG of patients with diabetic nephropathy were detected by immunoturbidimetry.Results The concentrations of serum Cys C,urinary α1-MG and β2-MG were significantly higher in patiens of diabetic nephro-pathy than in those of controls.Compared with the determination of a single or two markers,the combined determination of the three markers raised the positive rate of patients with diabetic nephropathy.Conclusion Serum Cys C,urinary α1-MG and β2-MG are sensitive markers for glomerular filtration rate and can indicate early renal impairment in patients.

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What this paper is about

Objective To explore the early diagnostic value of combined determination of serum Cys C,urine α1-MG and β2-MG in diabetic nephropathy.Methods Serum Cys C,urinary α1-MG and β2-MG of patients with diabetic nephropathy were detected by immunoturbidimetry.Results The concentrations of serum Cys C,urinary α1-MG and β2-MG were significantly higher in patiens of diabetic nephro-pathy than in those of controls.Compared with the determination of a single or two markers,the combined determination of the three markers raised the positive rate of patients with diabetic nephropathy.Conclusion Serum Cys C,urinary α1-MG and β2-MG are sensitive markers for glomerular filtration rate and can indicate early renal impairment in patients.

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Available abstract

Objective To explore the early diagnostic value of combined determination of serum Cys C,urine α1-MG and β2-MG in diabetic nephropathy.Methods Serum Cys C,urinary α1-MG and β2-MG of patients with diabetic nephropathy were detected by immunoturbidimetry.Results The concentrations of serum Cys C,urinary α1-MG and β2-MG were significantly higher in patiens of diabetic nephro-pathy than in those of controls.Compared with the determination of a single or two markers,the combined determination of the three markers raised the positive rate of patients with diabetic nephropathy.Conclusion Serum Cys C,urinary α1-MG and β2-MG are sensitive markers for glomerular filtration rate and can indicate early renal impairment in patients.

Key concepts: Diabetic nephropathy, Urine, Medicine, Urinary system, Renal function, Internal medicine, Nephropathy, Endocrinology

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The early diagnostic value of combined determination of serum Cys C and urine microprotein in diabetic nephropathy — Research Paper | ScholarLens