Diagnostic significance of urine NAG combined with serum Cys-C in diabetic nephropathy

Objective To study the expression level of urinary NAG and serum Cys-C in different stages of diabetic nephropathy,and to explore the diagnostic significance in diabetic nephropathy.Methods A total of 252 cases of hospitalized patients with type 2 diabetes admitted in our hospital were divided into three groups according to the urine albumin excretion(UAE),81 cases in normal albuminuria group(group A) : 30 mg/d;85 cases in microalbuminuria group(group B) :(30-300) mg/d;86 cases in lots of proteinuria group(group C):300 mg/d.Detected the urine NAG and serum Cys-C level in urine samples and blood samples.Results(1)Compared with control group,the urine NAG of the other two groups increased significantly,and gradually increased along with the development of diabetic nephropathy.(2)The serum Cys-C level increased in the normal albuminuria period,gradually increased along with the development of diabetic nephropathy,and earlier than the rising of creatinine.(3)The combined detection of urine NAG and serum Cys-C significantly increased the diagnostic rate of diabetic nephropathy.Conclusion Urinary NAG and serum Cys-C are early diagnosis indicators of diabetic nephropathy,and the combined use of them can significantly increase the early diagnostic rate of diabetic nephropathy.