ScholarLens Back to search
2012•动物与饲料科学：英文版Requires access

The Antioxidant Effects of L-carnitine on D-galactose Induced Aging Mice

Luan, Haiyun, Yang, Ming Ming, Wang, Guihua Guihua, Li

Open publisher page 0 citations

Abstract

[Objective] To study the antioxidant effects of LC on D-galactose induced aging mice. [Method] 50 mice were randomly divided into blank control group, D-galactose model group, LC treatment groups at three levels of 0.25, 0.5 and 1.0 g/(kg·d), a total of 5 groups. Using the subacute D-galactose induced aging models, the mice were killed after 6 weeks of experiment and the activity of Superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px) and Malondialdehyde (MDA) content in plasma, brain and liver tissue were determined. [Result] The activity of SOD and GSH-Px in plasma, brain and liver tissue were significantly increased after treated with LC, while the content of MDA were decreased with a dose-dependent manner. [Conclusion] LC had anti-aging effects in mice, and the mechanism may be correlated with the antioxidation.

About this research paper

What this paper is about

[Objective] To study the antioxidant effects of LC on D-galactose induced aging mice. [Method] 50 mice were randomly divided into blank control group, D-galactose model group, LC treatment groups at three levels of 0.25, 0.5 and 1.0 g/(kg·d), a total of 5 groups. Using the subacute D-galactose induced aging models, the mice were killed after 6 weeks of experiment and the activity of Superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px) and Malondialdehyde (MDA) content in plasma, brain and liver tissue were determined. [Result] The activity of SOD and GSH-Px in plasma, brain and liver tissue were significantly increased after treated with LC, while the content of MDA were decreased with a dose-dependent manner. [Conclusion] LC had anti-aging effects in mice, and the mechanism may be correlated with the antioxidation.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

[Objective] To study the antioxidant effects of LC on D-galactose induced aging mice. [Method] 50 mice were randomly divided into blank control group, D-galactose model group, LC treatment groups at three levels of 0.25, 0.5 and 1.0 g/(kg·d), a total of 5 groups. Using the subacute D-galactose induced aging models, the mice were killed after 6 weeks of experiment and the activity of Superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px) and Malondialdehyde (MDA) content in plasma, brain and liver tissue were determined. [Result] The activity of SOD and GSH-Px in plasma, brain and liver tissue were significantly increased after treated with LC, while the content of MDA were decreased with a dose-dependent manner. [Conclusion] LC had anti-aging effects in mice, and the mechanism may be correlated with the antioxidation.

Key concepts: Malondialdehyde, Superoxide dismutase, Chemistry, Glutathione peroxidase, Antioxidant, Galactose, Endocrinology, Internal medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The Antioxidant Effects of L-carnitine on D-galactose Induced Aging Mice — Research Paper | ScholarLens