Clinical Observation of Fluoxetine on Post-stroke Depression and Neurologic Impairment

Objective: To observe the efficacy of fluoxetine on post -stroke depression and neurologic impairment. Methods: 86 cases of post-stroke depression patients were randomly divided into two groups with 43 cases respectively, the patients in the treatment group were administered with fluoxetine besides conventional way, The control group were treated with conventional way. Then, Hamilton Depression Scale (HAMD), Barthel Index (BI) and Scandinavian Stroke Scale (SSS) were used to evaluate the curative effect and adverse effects between the two groups before and after the treatment. Results: There was a marked decline of HAMD score in the treatment group after the treatment compared with that before the treatment (P 0.01). However, there was no difference in the control group after the treatment compared with that before the treatment in same time (P0.05); There was a marked decline of SSS score in the treatment group compared with that before the treatment (P0.01), and, a marked elevation of BI score in the treatment group compared with that before the treatment (P 0.01). Conclusion: Fluoxetine is effective in treatment of post -stroke depression and is prominent on the process of neurofunctional rehabilitation with a little adverse effects.