Clinical analysis of Fluoxetine hydrochloride in the treatment of post-stroke depression

Objective To observe the clinic efficacy of Fluoxetine on post-stroke depression.Methods One hundred and twenty cases of post-stroke depression patients were randomly divided into the observation group(add with hydrochloric acid prozac) and the control group(conventional treatment) according to the doctor order,each group of 60 cases,the patients in the observation group were administered with Fuoxetine besides conventional way,the control group were treated with conventional way.Then,Hamilton Depression Scale(HAMD),National Institute of Health stroke scale(NIHSS) and Barthel Index(BI) were used to evaluate the curative effect and adverse effects between the two groups.Results After treatment of 8 weeks,Hamilton Depression Rating Scale(HAMD) and Neural Function Defect score(NIHSS) of two groups were significantly decreased(P 0.05 or P 0.01),and the range of decrease in obsevation group was more significant than control group(P 0.01).And there was a marked elevation of Barthel score in the obsevation group compared with the control group(P 0.01).Conclusion Fluoxetine is effective in treatment of post-stroke depression and is prominent on the process of neurofunctional rehabilitation with a little adverse effects.