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IMMUNOHISTOCHEMICAL DETECTION OF P73 PRODUCTIN BRAIN GLIOMAS

Zhai Guan

Abstract

Objective: To elucidate the role of p73 in the genesisor development of glioma. Methods: P73 and p53expression of 63 gliomas were detected by immunohistochemistry. Results: Out of the 63 gliomas, 17 casesappeared p73 positive. The positive-rate in high gradegliomas was higher than that in low grade gliomas(x2=4.75, P0.05). Among the 17 cases with p73-positivegliomas, 12 cases overexpressed p53 proteill. Conclusion:Overexpression of wild p73 may involve in the genesis ordevelopment of glioma.

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Key concepts: Immunohistochemistry, Glioma, Pathology, Medicine, Biology, Cancer research