2008•Chinese Journal of Neurosurgical Disease ResearchRequires access
Research on expression of stathmin/oncoprotein18 (Op18) gene in human brain gliomas
Xiaoqian Liu
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Abstract
Objective To investigate the expression of Stathmin/oncoprotein 18 (Op18) in human brain gliomas and its significance.Methods Fifty-six cases of human brain gliomas were examined by immunohistochemical staining and Western blot method (including 10 cases of normal cerebral tissues).Results The immunohistochemical analysis demonstrated that the positive rate of Stathmin in normal human brain tissues, grade Ⅰ~Ⅱ gliomas and grade Ⅲ~Ⅳ gliomas were 20%, 65% and 100% respectively. There was significant difference between normal human brain tissues and grade Ⅰ~Ⅱ glioma, grade Ⅲ~Ⅳ gliomas (P0.05) respectively; the difference between Ⅰ~Ⅱ grade glioma and Ⅲ~Ⅳ grade glioma was significant (P0.05). The expression level of stathmin in the gliomas was higher than that of normal brain tissues by Western blot method. There were significant difference between normal brain tissues and grade Ⅰ~Ⅱ glioma, grade Ⅲ~Ⅳ glioma (P0.01) respectively; the differences between grade Ⅰ~Ⅱ glioma and grade Ⅲ~Ⅳ glioma were significant (P0.01). Conclusion Stathmin overexpresses in human brain gliomas which may be a new biotherapy target in the treatment of brain gliomas.