ScholarLens Back to search
2011•Shanxi Yike Daxue xuebaoRequires access

Expression of p33~(ING1b) and p53 gene in brain glioma and their relations

Lin Zhi-ping

Open publisher page 1 citations

Abstract

Objective To explore the expression of p33ING1b and p53 gene in brain gliomas and their relationship.Methods Immunohistochemical SP staining was used to examine the expression of p33ING1b and p53 in 40 fresh samples of gliomas and 10 control tissues.The SPSS11.5 was used for statistical analysis.Results The positive rate of p33ING1b expression was 77.5%(31/40) in gliomas and 100% in normal controls.The positive expression rate of p53 was 37.5%(15/40) in gliomas.The expression of p33ING1b decreased with the increase of tumor grade,while p53 expression increased.Labeling index(LI) of p33ING1b expression was negatively correlated with p53 expression in brain glioma.Conclusion In brain glioma,p33ING1b and p53 are negatively correlated,which may play an important role in the occurrence and development of gliomas.

About this research paper

What this paper is about

Objective To explore the expression of p33ING1b and p53 gene in brain gliomas and their relationship.Methods Immunohistochemical SP staining was used to examine the expression of p33ING1b and p53 in 40 fresh samples of gliomas and 10 control tissues.The SPSS11.5 was used for statistical analysis.Results The positive rate of p33ING1b expression was 77.5%(31/40) in gliomas and 100% in normal controls.The positive expression rate of p53 was 37.5%(15/40) in gliomas.The expression of p33ING1b decreased with the increase of tumor grade,while p53 expression increased.Labeling index(LI) of p33ING1b expression was negatively correlated with p53 expression in brain glioma.Conclusion In brain glioma,p33ING1b and p53 are negatively correlated,which may play an important role in the occurrence and development of gliomas.

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To explore the expression of p33ING1b and p53 gene in brain gliomas and their relationship.Methods Immunohistochemical SP staining was used to examine the expression of p33ING1b and p53 in 40 fresh samples of gliomas and 10 control tissues.The SPSS11.5 was used for statistical analysis.Results The positive rate of p33ING1b expression was 77.5%(31/40) in gliomas and 100% in normal controls.The positive expression rate of p53 was 37.5%(15/40) in gliomas.The expression of p33ING1b decreased with the increase of tumor grade,while p53 expression increased.Labeling index(LI) of p33ING1b expression was negatively correlated with p53 expression in brain glioma.Conclusion In brain glioma,p33ING1b and p53 are negatively correlated,which may play an important role in the occurrence and development of gliomas.

Key concepts: Glioma, Immunohistochemistry, Gene expression, Cancer research, Pathology, Gene, Medicine, Biology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Expression of p33~(ING1b) and p53 gene in brain glioma and their relations — Research Paper | ScholarLens