Observation of efficacy and safety of preemptive analgesia with parecoxib sodium for sixty perioperative snoring patients

Objective To observe efficacy and safety of preemptive analgesia with parecoxib sodium for perioperative snoring patient.Methods Sixty surgical snoring patients were randomly divided into two groups: parecoxib sodium group(A) was given 40 mg parecoxib sodium(diluted with 10 mL normal saline) at 30 minutes before the end of surgery,and matched group was given 10 mL normal saline.To observe and record systolic blood pressure(SBP),diastolic blood pressure(DBP) and heart rate(HR) after intubation,extubation,and to calculate the maximum rate of change.VAS score,agitation score,Ramsay sedation score at 1,3,6,18,24 h after extubation,and adverse reactions were recorded after surgry.Results SBP,DBP and HR in parecoxib sodium group(A) are lower than those in the matched group(B)(P0.05) during extubation,and the maximum change rate in group A is less than that in the B group(P0.05).VAS score of parecoxib sodium group at each time point was significantly lower than that in the matched group(P0.05),postoperative sedation score is higher than that in the matched group(P0.05).Agitation rate in group A is less than that in group B(P0.05).There is no significant difference in adverse reactions such as nausea,vomiting and dizziness between group A and matched group(P0.05).Conclusion Preemptive analgesia with parecoxib sodium is a safe and reliable analgesia pattern,which can reduce the postoperative pain and restlessness of surgical snoring patient,improve comfort index of patients.