Clinical Study of Preemptive Analgesia with Parecoxib Sodium in Children Undergoing Upper Limb Orthopedic Surgery

Objective To study the efficacy and safety of preemptive analgesia with parecoxib sodium in children undergoing upper limb orthopedic surgery.Methods Ninety children from June 2009 to December 2010 scheduled for elective upper limb orthopedic surgery under general anesthesia were selected and randomly divided into three groups with 30 children in each.For the children in group P(parecoxib sodium),group T(tramadol) and group C(control),preemptive analgesia was induced by an intravenous injection of parecoxib sodium at 1 mg/kg,tramadol at 2 mg/kg,and normal saline respectively before anesthesia.Pain intensity score and sedation score were recorded 2,4,6,and 8 hours respectively after operation.The agitation score was measured 5 minutes after extubation.The perioperative fentanyl consumption and postoperative analgesic medicine consumption were recorded.The adverse effects were observed within 24 hours after operation.Results The demographic data such as age,gender,weight,and operation time did not differ statistically among the three groups of children(P0.05).Compared with groups T and C,the pain score in group P was significantly lower at all time points after operation(P0.01).The sedation score in group T was significantly higher than those in group P and C 2,4,and 6 hours after operation(P0.01),but the sedation score did not differ significantly between groups P and C(P0.05).The agitation score after trachea extubation in group P was significantly lower than the other two groups(P0.01).The quantity of fentanyl used in group P was significantly lower than in groups T and C(P0.01).The incidence of postoperative nausea or vomiting in group T was higher than those in groups P and C(P0.05).There was no depression of breath or abnormal hemorrhage in group P.Conclusion Parecoxib sodium has a better analgesic effect in children undergoing upper limb orthopedic surgery.The agitation score and the incidence of postoperative nausea or vomiting are significantly lower,and the use of parecoxib sodium can also significantly reduce the perioperative fentanyl consumption.