Clinical efficacy of parecoxib sodium on preemptive analgesia in patients undergoing endoscopic sinus surgery

Objective To observe the preemptive analgesia of parecoxib sodium on endoscopic sinus surgery.Methods Fifty-six cases were divided into control group and experiment group randomly(n=28 in each group).The amount of anesthetic use was recorded.The pain score was evaluated with VAS and BCS after the operation 24 h.The RS and RSS were measured 10 min before tracheal extubation(T1),tracheal extubation(T2),and 10min after tracheal extubation(T3).The incidence of adverse events was recorded after the operation.Results Compared with control group,the amount of anesthetic use wasn’t reduced in parecoxib sodium group.The VAS scores of parecoxib sodium group lower than control group at 2 h,6 h,12 h after surgery(P 0.05).The BCS scores of parecoxib sodium group higher than control group at 2 h,6 h,12 h after surgery(P 0.05).The RS scores of parecoxib sodium group lower than control group at T1,T2,T3 in resuscitation after general anesthesia(P 0.05).Furthermore,the RSS scores of parecoxib sodium group higher than control group at T2,T3 in resuscitation after general anesthesia(P 0.05).Parecoxib sodium can effectively reduce the fever of postoperative patient.Conclusion The preincisional administration of parecoxib sodium after endoscopic sinus surgery result significant preemptive analgesic effect,reduce postoperative pain and emergence agitation.