2016•International Journal of Latest Research in Science and TechnologyRequires access
The Mediating Role of Radical Innovation in the Relationship Between Knowledge Management and Competitive Advantage in Sudanese Manufacturing Firms
Ganesh Adhikari
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Abstract
The advent of human epidermal growth factor receptor-2 (HER2) Status and biomarker testing has modified the treatment and prognosis of gastric, breast and colorectal cancer. Epidermal growth factor receptor and HER-2 family maneuvers a key role in the exploitation of gastric cancer by detecting the epidermis express in gastric cancer tissue and to investigate serum and tissue HER2. Targeted drugs i.e. antineoplastic therapies such as EGFR tyrosine kinase inhibitors have application in the treatment of gastric cancer.
OBJECTIVES: To scrutinize the manifestation of HER2 in gastric cancer and assess their association with clinic-pathological hallmarks: the tumorigenesis and the metastasis of gastric tumor.
METHODS: 1. Analysis of a prospective database with 68 patients for gastric cancer in the first affiliated hospital of Anhui Medical University range from 2013.4-2014.3 Immunohistochemistry staining(IHC) was used to detect the expression of tissue HER2 in 68 cases of gastric cancer and adjacent non-cancer tissue and 40 cases of adjacent normal EGFR and HER2. Preoperative serum samples were extracted from 68 gastric tumor patients and 40 healthy volunteers. Serum and tissue of HER2 were determined using an enzyme-linked immunosorbent assay (ELISA).
2. To analysis the relationship of clinic pathological features with the expressions HER2 and the correlation of diagnosis and prognosis with gastric cancer.
3.All data were processed by SPPSS.13.0
Results: There was significant difference between the overexpression of Her2 in gastric cancer and the low expression in adjacent non-cancer tissue and adjacent normal epithelial tissuei¼ˆPi¼œ0.01. Serum Her2 were significantly higher in patients with gastric cancer than those in normal control groupi¼ˆPi¼œ0.01i¼‰. The Her2 levels have no relationship to sex, age, tumor location and histological gradesi¼ˆPi¼ž0.05i¼‰, but had significantly statistic difference between lymph node metastasis, Histological differentiation and Dukes stagei¼ˆPi¼œ0.01).
CONCLUSION: The overexpression of Her2 in gastric cancer apprise that the HER2 may maneuver an important role in progression of gastric cancer; serum HER2 can be used as a new tumor marker to esteem the procession of gastric cancer.