2010•Zhonghua zhongliu fangzhi zazhiRequires access

Expression of HER-2 in gastric cancer tissues and its correlation with clinical pathological factors

Jianbo Zhang

Abstract

OBJECTIVE:To study the relationship between the expressions of HER-2 and pathological behaviors of gastric cancer tissues.METHODS:The expressions of HER-2 in 126 gastric cancer specimens and 30 normal gastric specimens from patients with gastric cancer were detected by immunohistochemistry.RESULTS:The positive rate of HER-2 expression was 29.4% (37/126) in gastric cancer tissues,and HER-2 was not found in normal tissues(P0.05),which was closely correlated with age,site of tumor,regional lymph node,distant metastasis,histologic grade,stage and prognosis (P0.05),and not corelated with sex,nerver infiltrating,and vessel infiltrating,P0.05.CONCLUSION:The expression of HER-2 has a closely relationship with biological behaviors of human gastric cancer.

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Key concepts: Pathological, Immunohistochemistry, Cancer, Pathology, Lymph node metastasis, Stage (stratigraphy), Distant metastasis, Medicine