Antioxidant Function of Flavonoids from Songaria cynomorium Herb

[Objective]To investigate the effect of flavonoids from Songaria cynomorium Herb on antioxidant function of aging mice. [Method]Forty 9-month-old female Kunming mice were randomly divided into four groups. In control group,mice were given sterile water by gavage; in the low, medium and high dose groups,mice were given solutions of S. cynomorium extract powder and sterile water by gavage for 54 d,with the flavonoids doses of 0. 08,0. 17 and 0. 50 g /kg BW,respectively. Changes of SOD,MDA,and myocardial lipofuscin were determined according to the instructions of kits. [Result]Compared with the control group,the activity of SOD was increased significantly by 18. 6%( P 0. 05) ,19. 5% ( P 0. 05) and 22. 7% ( P 0. 01) in low,high and medium dose groups,respectively. MDA content was reduced in three dose groups,which were 15. 0%( P 0. 05) in medium dose group and 26. 0%( P 0. 01) in high dose group. Myocardial lipofuscin content was also decreased,in three dose groups, which were 11. 2% and 9. 7% in medium dose group and high dose group,respectively. [Conclusion]Flavones extracted from S,cynomorium by ultrasonic technique have antioxidation activity.