Antioxidant Function of Flavonoids from Cynomorium songaricum Rupr.

[Objective] The aim was to explore the effects of flavonoids extracted from Cynomorium Songaricum Rupr.on the antioxidant function of aging mice.[Method]9-month-old female Kunming mice were divided randomly into four groups.In control group,mice were given sterile water by gavage;in the low,medium and high dose groups,mice were given solutions of Cynomorium Songaricum Rupr.extract powder and sterile water by gavage for 54 d,with the flavonoids doses of BW 0.08,0.17,and 0.50 g/kg,respectively.Changes of SOD,MDA,and myocardial lipofuscin were determined according to the instructions of kits.[Result] Compared with the control group,the activity of SOD increased significantly by 18.6%(P0.05),19.5%(P0.05) and 22.7%(P0.01) in low,high and medium dose groups,respectively.MDA content reduced in three dose groups,which were 15.0%(P0.05)in medium dose group and 26.0%(P0.01)in high dose group.Myocardial lipofuscin content also decreased,in three dose groups,which were 11.2% and 9.7% in medium dose group and high dose group,respectively.[Conclusion] Flavonoids extracted from Cynomorium Songaricum Rupr.by ultrasound had certain antioxidation activity.