Clinicopathological analysis of solitary fibrous tumor in 11 patients

Objective To evaluate the clinicopathological characteristics and immunophenotype of solitary fibrous tumor (SFT), which is able to provide the basis for clinical diagnosis and prognosis, differential diagnosis and predictable prognosis. Methods Data from 11 cases of SFT were investigated by immunohistochemical. Results Histologically, SFT was composed of spindle cells, which arranged in fascicles pattern, as well as the collagen and branch vessels. Malignant SFT had higher and crowed cellularity with significant pleomorphism, numerous mitoses and putrescence. Positivity for bcl-2 and CD34 was observed in all SFT. Eight tissues showed CD99 positivity, one showed s-100 positivity, all 11 tissues showed Ckpan negativity. Conclusions SFT has originated from different sites, which should be distinguished with fibrosarcoma and other spindle cell neoplasms. More attentions should be paid to malignant SFT and focus on the follow-up visit. Key words: Solitary fibrous tumor; Immunohistopathology; Differential diagnosis