Clinicopathologic Analysis of Solitary Fibrous Tumor

Objective To study the clinical and pathological features of solitary fibrous tumor(SFT) and improve the diagnosis of the SFT.Methods The clinical and pathological characteristics were studied by hematoxylin and eosin staining and immunohistochemical staining(Envision method) in 13 cases of SFT.Results The 8 male and 5 female patients were between 16 and 68 years of age(mean45).Their SFT were located in soft tissue,abdominal cavity,mediastinum,pleura,and lung.The main clinical manifestations were local mass and pressure symptom.The diameter of SFTs was between 1.5 and 20 cm and clear edge in most SFTs.Histologically,The tumors were characterized by a variety growth patterns,including the spindle cells composed of alternating hypercellular and hypocellular areas,keloid-like collagen bundles in the stroma,and hemangiopericytoma-like regions.Positive immunohistochemical staining was vimentin 13,Bcl-2 13,CD34 11,CD99 10.Conclusion SFT is a rare tumor which may be found in various parts of human body.SFT mostly is a benign tumor,but a few could be malignant.The pathologic conformation of SFT cannot always predicts biological behaviors.The outcome in patients with SFT depends on factors including tumor size and its modes of growth.If tumor could be removed completely,the patients may have a good prognosis.Long-term clinical follow-up is necessary for this kind of tumor.