Solitary fibrous tumor:a clinicopathologic study of 35 cases

Objective To observe the clinicopathological and immunophenotype characteristics of solitary fibrous tumor,and to explore the diagnosis,differential diagnosis and prognosis of solitary fibrous tumor(SFT).Methods The clinical and pathological characteristics were studied by hematoxylin and eosin stain and immunohistochemical techniques in 35 cases of SFT.Results The age of the patients with SFT ranged from 9 to 79 years.The ratio of male to female was 1.2∶1.SFT occurred in thirteen sites.Histologically,the tumors were characterized by a variety of growth patterns,including the spindle cells composed of hypo-and hypercellular areas,keloid-like collagen bundles in the stroma,thin-walled branching vessels showing an HPC-like growth pattern,and prominent vascularity with numerous small and mid-sized vessels,occasionally with the area of myxoid,cystic and fatty degeneration. Conclusion The SFT mostly is a benign tumor,but a few could be malignant.The pathologic appearance of SFT cannot always predicts clinical behaviors(morphologically,some benign SFT may be invasive).Therefore it is very important to follow-up all of SFT.Usually,patients with a pedunculated tumor and its complete excision has a good prognosis.