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2008•Chinese Journal of AsthmaRequires access

Progress of Th2 cytokines and bronchial asthma pathogenesis

Na Hu, Hong Wang

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Abstract

Bronchial asthma(asthma) is a chronic inflammatory disease of the lung,which is involvedwith various cells and cytokines. The pathogenesis of asthma is not well-known yet. Now it is recognized thatthe imbalance of Th1/Th2 response leading to excessive activation of the Th2 cells is one of the importantmechanisms of immunology. The polyphenic cytokines produced by Th2 cells,such as IL-4,IL-5 and IL-13,have been certified to play a significant role in this process and are related with asthma pathogenesis. Key words: Th2 cytokines; Bronchial asthma; Pathogenesis; Progress

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What this paper is about

Bronchial asthma(asthma) is a chronic inflammatory disease of the lung,which is involvedwith various cells and cytokines. The pathogenesis of asthma is not well-known yet. Now it is recognized thatthe imbalance of Th1/Th2 response leading to excessive activation of the Th2 cells is one of the importantmechanisms of immunology. The polyphenic cytokines produced by Th2 cells,such as IL-4,IL-5 and IL-13,have been certified to play a significant role in this process and are related with asthma pathogenesis. Key words: Th2 cytokines; Bronchial asthma; Pathogenesis; Progress

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Available abstract

Bronchial asthma(asthma) is a chronic inflammatory disease of the lung,which is involvedwith various cells and cytokines. The pathogenesis of asthma is not well-known yet. Now it is recognized thatthe imbalance of Th1/Th2 response leading to excessive activation of the Th2 cells is one of the importantmechanisms of immunology. The polyphenic cytokines produced by Th2 cells,such as IL-4,IL-5 and IL-13,have been certified to play a significant role in this process and are related with asthma pathogenesis. Key words: Th2 cytokines; Bronchial asthma; Pathogenesis; Progress

Key concepts: Pathogenesis, Medicine, Asthma, Immunology, Disease, Pathology

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