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2012•Chinese Journal of AsthmaRequires access

Role of interleukin-35 in the mechanism of bronchial asthma

Xiang Gu, Jiquan Chen, Bing Li

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Abstract

Bronchial asthma (asthma) is a chronic inflammatory airway disease involved in many cytokines,the mechanism may be related with the imbalance of Th1/Th2 cells or the abnormalities of CD4+CD25+T cells,Th17/IL-17 and so on.Interleukin-35 (IL-35) is a newly discovered cytokine,which is closely related to the immune function of Th17/IL-17 and Tregs.IL-35 may be involved in the pathogenesis of asthma,which is expected to become a new target for the treatment of asthma.This review describes the relative researches on IL-35. Key words: Interleukin-35 ;  Asthma ;  Pathogenesis ;  Treatment

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What this paper is about

Bronchial asthma (asthma) is a chronic inflammatory airway disease involved in many cytokines,the mechanism may be related with the imbalance of Th1/Th2 cells or the abnormalities of CD4+CD25+T cells,Th17/IL-17 and so on.Interleukin-35 (IL-35) is a newly discovered cytokine,which is closely related to the immune function of Th17/IL-17 and Tregs.IL-35 may be involved in the pathogenesis of asthma,which is expected to become a new target for the treatment of asthma.This review describes the relative researches on IL-35. Key words: Interleukin-35 ;  Asthma ;  Pathogenesis ;  Treatment

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Available abstract

Bronchial asthma (asthma) is a chronic inflammatory airway disease involved in many cytokines,the mechanism may be related with the imbalance of Th1/Th2 cells or the abnormalities of CD4+CD25+T cells,Th17/IL-17 and so on.Interleukin-35 (IL-35) is a newly discovered cytokine,which is closely related to the immune function of Th17/IL-17 and Tregs.IL-35 may be involved in the pathogenesis of asthma,which is expected to become a new target for the treatment of asthma.This review describes the relative researches on IL-35. Key words: Interleukin-35 ;  Asthma ;  Pathogenesis ;  Treatment

Key concepts: Medicine, Asthma, Pathogenesis, Immunology, Mechanism (biology), Cytokine, Immune system, Disease

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