2011•International journal of pediatricsRequires access

Progress of asthma and Th17 cells

HU Yan-yan, Yating Wang

Abstract

Bronchial asthma is a chronic inflammation airway disease.The imbalance of T helper cell (Th) 1/Th2 immunity plays an important role in the pathogenesis of allergic asthma.Recent years a new T cell lineage has been recognized as Thl7 cells because they can produce cytokines interleukin-17.The new studies find that interleukin-17 is a negative regulator of asthma,and interleukin-17 or Th17 cells may represent an interesting therapeutic target in asthma. Key words: Bronchial asthma; Th17 cells; Interleukin-17

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Key concepts: Medicine, Asthma, Immunology, Pathogenesis, Interleukin 17, Disease, Inflammation, Regulator