Effects of ulinastatin combined with high frequency mechanical ventilation on ARDS and pulmonary function improvement

Objective To explore the efficacy of ulinastatin combined with high frequency mechanical ventilation for acute respiratory distress syndrome (ARDS) and its improvement of pulmonary function. Methods 80 patients with ARDS treated at our hospital from May, 2015 to April, 2017 were selected for the study and divided into an observation group (n=40) and a control group (n=40) by random number table method. The control group were treated with high frequency mechanical ventilation and the observation group with high frequency mechanical ventilation and ulinastatin. The occurrence of ventilator-associated pneumonia (VAP) and mortality and pulmonary function and changes of blood gas analysis indexes before and after treatment were compared between the two groups. Results The incidence of VAP and mortality were 5.00% and 2.50% in the observation group and were 22.50% and 12.50% in the control group, with statistical differences (bothP<0.05). After excluding the dead patients during the treatment, the levels of FEV1/FVC, PaO2, PaCO2, pH, and RR were significantly better after than before the treatment in both groups and were better in the observation group than in the control group after the treatment, with statistical differences (allP<0.05). Conclusion Ulinastatin combined with high frequency mechanical ventilation in the treatment of patients with ARDS can significantly improve pulmonary function and respiratory disorder, inhibit lung inflammation, reduce the risk of complications, and improve the patients' survival rate and is safe. Therefore, it is worth being generalized. Key words: Ulinastatin; High frequency mechanical ventilation; Acute respiratory distress syndrome; Efficacy; Pulmonary function