Clinical effect and safety of noninvasive mechanical ventilation combined with ulinastatin in treatment of patients with ARDS

Objective To explore the clinical effect and safety of noninvasive mechanical ventilation combined with ulinastatin in treatment of patients with acute respiratory distress syndrome (ARDS). Methods Eighty-two patients with ARDS accepted in our hospital from Mar.2011 to Mar.2015 were selected and randomly divided into observation group and control group with 41 cases in each.Patients in control group underwent noninvasive mechanical ventilation, while in observation group accepted ulinastatin additionally.Then the clinical effect, indexes of arterial blood gases (ABG), expression levels of inflammatory factors, safety and life quality of two groups were compared. Results The total efficacy of observation group (92.68%) was obviously higher than control group (70.73%) with statistically significance (P 0.05). The improvement rate of life quality of observation group (90.24%) was remarkably higher than control group (65.85%) with statistically significance (P<0.05). Conclusions Using noninvasive mechanical ventilation combined with ulinastatin has good efficacy and safety in treatment of patients with ARDS.It can reduce the expression level of infammatory factors and improve the life quality, which is worth of clinical applications. Key words: Acute respiratory distress syndrome; Noninvasive mechanical ventilation; Ulinastatin