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2013•Zhonghua shiyan waike zazhiRequires access

Expression and significance of matrix metalloproteinase-2 and E-cadherin in bladder transitional cell carcinoma

Weibo Xu, Junqing Hou, Xinyi Du, Xiaozhen Li, Zhaoyang Zhu

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Abstract

Objective To explore the clinical significance and expression of matrix metalloproteinase (MMP)-2 and E-cadherin in bladder transitional cell carcinoma.Methods Immunohistochemistry was used to detect the expression of MMP-2 and E-cadherin in 48 cases of bladder transitional cell carcinoma,and the relationship between their expression and clinicopathological features was analyzed.Results The expression of MMP-2 and E-cadherin had a negative correlation (P ＜ 0.05),and the positive expression rate was 75.0％ and 47.9％ respectively.MMP-2 and E-cadherin were related to tumor pathological grade and clinical stage.Conclusion Detection of MMP-2 and E-cadherin can help determine the invasion and metastasis ability of bladder transitional cell carcinoma. Key words: Bladder transitional cell carcinoma;  Matrix metalloproteinase-2 ;  E-cadherin ; Immunohistochemistry

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Objective To explore the clinical significance and expression of matrix metalloproteinase (MMP)-2 and E-cadherin in bladder transitional cell carcinoma.Methods Immunohistochemistry was used to detect the expression of MMP-2 and E-cadherin in 48 cases of bladder transitional cell carcinoma,and the relationship between their expression and clinicopathological features was analyzed.Results The expression of MMP-2 and E-cadherin had a negative correlation (P ＜ 0.05),and the positive expression rate was 75.0％ and 47.9％ respectively.MMP-2 and E-cadherin were related to tumor pathological grade and clinical stage.Conclusion Detection of MMP-2 and E-cadherin can help determine the invasion and metastasis ability of bladder transitional cell carcinoma. Key words: Bladder transitional cell carcinoma;  Matrix metalloproteinase-2 ;  E-cadherin ; Immunohistochemistry

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Available abstract

Objective To explore the clinical significance and expression of matrix metalloproteinase (MMP)-2 and E-cadherin in bladder transitional cell carcinoma.Methods Immunohistochemistry was used to detect the expression of MMP-2 and E-cadherin in 48 cases of bladder transitional cell carcinoma,and the relationship between their expression and clinicopathological features was analyzed.Results The expression of MMP-2 and E-cadherin had a negative correlation (P ＜ 0.05),and the positive expression rate was 75.0％ and 47.9％ respectively.MMP-2 and E-cadherin were related to tumor pathological grade and clinical stage.Conclusion Detection of MMP-2 and E-cadherin can help determine the invasion and metastasis ability of bladder transitional cell carcinoma. Key words: Bladder transitional cell carcinoma;  Matrix metalloproteinase-2 ;  E-cadherin ; Immunohistochemistry

Key concepts: Transitional cell carcinoma, Cadherin, Immunohistochemistry, Matrix metalloproteinase, Pathology, Metastasis, Stage (stratigraphy), Pathological

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Expression and significance of matrix metalloproteinase-2 and E-cadherin in bladder transitional cell carcinoma — Research Paper | ScholarLens