2015•Zhonghua shiyan waike zazhiRequires access
The expression and significance of Ki-67 and E-cadherin in bladde transitional cell carcinoma
Weibo Xu, Junqing Hou, Guangchao Liu, Xinyi Du, Tie‐Qiang Li
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Abstract
Objective
To explore the clinical significance and expression of proliferation cell nuclear antigen(Ki- 67)and E- cadherin in bladder transitional cell carcinoma.
Methods
Immunohistochemistry was applied to detect the expression of Ki-67 and E-cadherin in 48 cases of bladder transitional cell carcinoma, and the relationship between their expression and clinicopathological features was analyzed.
Results
The expression of Ki-67 and E-cadherin was negatively correlated (P<0.05), and their positive rate was 83.3% and 47.9% respectively. They were related to tumor pathological grade and clinical stage.
Conclusion
Detection of Ki-67 and E-cadherin will help determine the invasion and metastasis ability of bladder transitional cell carcinoma.
Key words:
Bladder transitional cell carcinoma; Proliferation cell nuclear antigen; E-cadherin