Diagnostic value of serum related factors and urinary albumin to creatinine ratio in early renal damage of hypertension

Objective To investigate the diagnostic values of serum cystatin C (Cyst-C), urinary albumin to creatinine ratio (UACr), and endothelin -1 (ET-1) in early renal damage of hypertension. Methods From February 2015 to September 2016 at our hospital, 94 patients with primary hypertension were enrolled as an observation group and 90 non-hypertensive patients a control group. According to the renal dynamic imaging, each group was divided into 2 subgroups, an early renal damage group and a normal renal function group. The observation indexes were focused on the serum Cyst-C, ET-1, and UACr. Results The serum levels of Cyst-C, UACr, and ET-1 were higher in the observation group than in the control group, with a significant increasing tendency as increment of blood pressure (P < 0.05). The combined detection rate of serum Cyst-C, UACr, and ET-1 was higher than that individually (P < 0.05). The serum levels of Cyst-C, UACr and ET-1 were higher in the observation group than in the control group in the patients with early renal damage (P < 0.05). Conclusions The serum levels of Cyst-C, UACr, and ET-1 increase with the progression of early renal damage in hypertensive patients; these indexes can be used as effective diagnostic factors for early renal damage and can improve the diagnostic value. Key words: Hypertension; Renal damage; Cystatin C; Urinary albumin to creatinine ratio; Endothelin -1