Evaluation of Serum Cystatin C (Cyst-c) Levels in Detecting Early Renal Damage in elderly Hypertensive Patients 1

Objective To study the value of serum Cystatin C (Cyst-c) levels in detecting early renal damage in old hypertension patients. Methods Serum Cyst-c and creatinine (Cr) levels were determined in 412 old hypertension patients and compare with a control group(n=30). Results Among 412 patients, there was early renal damage in 197 cases(47.82%), renal failure in 24 cases(5.82%), normal renal function in 191 cases(46.36%). Serum Cyst-c levels in the early renal damage group was higher than the controlled group [(2.34±0.8 and 0.9±0.2)mg/L, P＜0.01]. There was no difference in serum Cr levels between the early renal damage group and the control group [(86.6±12.7 and 81.0±10.5)μmol/L, P＞0.05]. Conclusion Serum Cyst-c levels is a sensitive indicator for detecting early renal damage which was not found by serum Cr.