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2014•Zhonghua shiyan waike zazhiRequires access

The expression and significance of proliferation cell nuclear antigen in renal cell carcinoma

Weibo Xu, Junqing Hou, Xinyi Du, Xiaozhen Li, Chao‐Yang Zhu

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Abstract

Objective To explore the clinical significance of proliferation cell nuclear antigen (Ki-67) expression in renal cell carcinoma (RCC).Methods The immunohistochemistry staining method was used to evaluate the expression of Ki-67 in 70 cases of RCC and 30 cases of normal renal tissue as controls.Results The positive expression rate of Ki-67 was 64.29％ in RCC.The positive expression rate of Ki-67 in RCC was significantly related to the clinical stage or clinical grade (P ＜ 0.05),but not to the types of RCC (P ＞0.05).Conclusion Ki-67 is an objective marker to estimate the behaviors of RCC. Key words: Renal cell carcinoma;  Proliferation cell nuclear antigen;  Biological behavior

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Objective To explore the clinical significance of proliferation cell nuclear antigen (Ki-67) expression in renal cell carcinoma (RCC).Methods The immunohistochemistry staining method was used to evaluate the expression of Ki-67 in 70 cases of RCC and 30 cases of normal renal tissue as controls.Results The positive expression rate of Ki-67 was 64.29％ in RCC.The positive expression rate of Ki-67 in RCC was significantly related to the clinical stage or clinical grade (P ＜ 0.05),but not to the types of RCC (P ＞0.05).Conclusion Ki-67 is an objective marker to estimate the behaviors of RCC. Key words: Renal cell carcinoma;  Proliferation cell nuclear antigen;  Biological behavior

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Available abstract

Objective To explore the clinical significance of proliferation cell nuclear antigen (Ki-67) expression in renal cell carcinoma (RCC).Methods The immunohistochemistry staining method was used to evaluate the expression of Ki-67 in 70 cases of RCC and 30 cases of normal renal tissue as controls.Results The positive expression rate of Ki-67 was 64.29％ in RCC.The positive expression rate of Ki-67 in RCC was significantly related to the clinical stage or clinical grade (P ＜ 0.05),but not to the types of RCC (P ＞0.05).Conclusion Ki-67 is an objective marker to estimate the behaviors of RCC. Key words: Renal cell carcinoma;  Proliferation cell nuclear antigen;  Biological behavior

Key concepts: Renal cell carcinoma, Immunohistochemistry, Proliferating cell nuclear antigen, Antigen, Staining, Clinical significance, Pathology, Cell growth

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