Effect of ventilator combined with pulmonary surfactant on severe meconium aspiration syndrome in newborns

Objective To investigate the clinical effects of combined use of ventilators and pulmonary surfactants on neonatal severe meconium aspiration syndrome. Methods Eighty-two children with neonatal meconium aspiration syndrome diagnosed in Shanxi Dayi Hospital from January 2017 to August 2018 were randomly divided into observation group(n=42) and control group(n=40). Both groups were treated by ventilator, and the children in the observation group were treated with pulmonary surfactant additionally. Results The ventilator-related parameters and the ventialtion duration of the neonates in the observation group were significantly better than those in the control group (P 0.05). The improvement of OI and a/APO2 in the observation group was better than that in the control group (P<0.05). The hospitalization time of the newborns in the observation group was (30.26±12.47) d, shorter than the (55.48±26.42)d of the control group, and the difference was significant(P<0.05). The complication rate and mortality of the newborns in the observation group were significantly lower than those in the control group (P<0.05). Conclusions The combination of respirator and pulmonary surfactant in the treatment of neonatal severe meconium aspiration syndrome can improve the therapeutic effect, reduce the complication rate and mortality of neonates, and improve the prognosis of neonates. Key words: Meconium aspiration syndrome; Neonatal; Ventilator; Pulmonary surfactant