28 case reports of surfactant therapy (Curosurt) in neonates with meconium aspiration syndrome

Objective: To study the efficacy of pulmonary surfactant (PS) in the newborn infants with severe meconium aspiration syndrome(MAS). Methods: 28 infants with severe MAS were randomly divided into two groups. The treatment group (13 cases) were treated with PS, control group (15 cases) were treated in usually way. Results: The mean oxygenation index (OI) of the PS group decreased from 21.5±4.6 to 12.8±1.6,which was significantly lower compared with control group (P 0.05); arterial/alveolar oxygen tension ratio (a/APO2) of the PS group increased form 0.10±0.04 to 0.31±0.05, which was significantly higher compared with control group (P 0.05). The durations of mechanical, oxygen therapy, and admission were significantly short in the PS group than in control group. Conclusion: PS therapy may result in a rapid improvement in oxygenation, and reduce the duration of mechanical ventilation and hospitalization time of newborn infants with severe MAS.