Distribution and drug resistance of Gram-negative bacteria in lower respiratory tract infections in patients in respiratory medicine departments

Objective To analyze the distribution and drug resistance of Gram-negative bacteria in lower respiratory tract infections in patients with respiratory medicine, so as to provide reference for improving clinical therapeutic effect, reducing the production of drug-resistant bacteria and selecting antibiotics rationally. Methods A total of 200 patients with lower respiratory tract infection who visited the Department of Respiratory Medicine of the Third Municipal Hospital of Weihai from April 2018 to May 2018 were selected as the research subjects. Sputum samples were taken from patients, and bacterial culture was carried out by routine isolation method; pathogenic bacteria were identified, and antimicrobial susceptibility tests were carried out for commonly used antimicrobials. Data of the study were analyzed by WHONET 5.3 software. Results Among 200 sputum samples of lower respiratory tract infection, 333 strains were isolated, of which 266 strains (79.89%) were gram-negative bacteria, including Klebsiella pneumoniae (52 strains, 19.55%), Pseudomonas aeruginosa (50 strains, 18.80%), Escherichia coli. (47 strains, 17.67%) and Acinetobacter baumannii (46 strains, 17.29%). The resistance of Acinetobacter baumannii to aztreonam, amikacin, piperacillin, cefoperazone, cefepime, ceftriaxone, ceftazidime, ceftitam and cefazolin was higher than 80.00%. Conclusions Gram-negative bacteria such as Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli. and Acinetobacter baumannii in lower respiratory tract infections have different susceptibility to different drugs. Clinicians should perform clear identify, closely monitoring and effectively intervention.And antibiotics protocols should be in accordance to drug sensitivity to reduce the production of drug-resistant strains. Key words: Respiratory medicine; Lower respiratory tract infection; Gram-negative bacteria; Drug resistance