Drug resistance surveillance of 1287 strains of gram-negative bacteria of lower respiratory tract

Objective: To investigate the distribution and drug resistance of Gbacteria from lower respiratory tract in our hospital,and to give the reliable foundation for rational use of antibiotics in clinical treatment. Methods: We cultivated and identified the pathogens isolated from the sputum samples from patients with lower respiratory tract infection with Gbacteria in wards of respiratory diseases from 2006 to 2008 in our hospital. Antimicrobial susceptibility was tested by Kirby-Baue method. Results:A total of 1 287 strains of G-bacteria were isolated, which were Pseudomonas aeruginosa 307 strains(23.9%),E.coli 271 strains(21.1%),Klebsiella 218 strains(16.9%)in sequence,Imipenem,Meraopenem,Cefoperazone/Sulbactam,Cefpine showed a very good antibacterial activity against Pseudomonas aeruginosa,Stenotrophomonas maltophiliam was resistant to almost all the clinical antibiotics.Conclusion:The drug resistance of Gbacteria from lower respiratory tract is serious insreasely.It is important and urgent to carry out surveillance of bacterial resistance for appropriate using of antibiotics effectively.