Distribution and Analysis of Drug Sensitivity of 328 Strains infected in Lower Respiratory Tract

Objective: To analyze the species and distribution of common pathogens in lower respiratory tract infection in hospitals,and to analyze the drug sensitivity results.It provides a clinical reference for the rational use of antimicrobial agents.Methods: The method recommended by Committee for Clinical Laboratory Standards (CLSI) in 2006 was referred to operate.The standard of CLSI in 2006 was used to determine the drug sensitivity,and the US Microscan A/S-4 semi-automatic bacterial identification and susceptibility analyzers were used.The drug sensitivity tests of 328 pathogenic bacteria isolated from the sputum samples in patients with lower respiratory tract infection on January 2008-December 2009 were analyzed.Results: In 328 pathogens isolated from the sputum samples,there were 217 strains gram-negative bacteria(66.19%) based mainly on Escherichia coli,Klebsiella pneumoniae,Pseudomonas aeruginosa and Bowman/Hemolytic Acinetobacter;There were 100 strains gram-positive bacteria(30.49%)based mainly on Staphylococcus aureus,Staphylococcus haemolyticus and Staphylococcus epidermidis;There were 11 strains other pathogens (3.35%).In gram-negative bacteria,the highest rate of antibiotic resistance was ampicillin(83.20%),ciprofloxacin(53.44%)and aztreonam(51.24%);In gram-positive bacteria,the highest rate of antibiotic resistance was penicillin(88.02%) and ticarcillin(65.15%).Conclusion: The patients with lower respiratory tract infection based mainly on gram-negative bacteria infection(66.19%).The higher resistance pathogens were Escherichia coli,Klebsiella pneumoniae and Pseudomonas aeruginosa.The clinicians should pay attention to the bacterial distribution and the rate of drug resistance in patients with lower respiratory tract bacterial infection.So that the antimicrobial drugs were used rationally.