2004Zhongguo jiceng yiyaoRequires access

Comparison of contents of the endothelin -1,tumor necrosis factor-α,hyaluronic aid and collagen type IV in patient with hepatocirrhosis

曾云, 向 红, 陈敏, 丁建中, 申群喜, 洪建琴

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Abstract

目的 比较肝硬化患者血浆内皮素-1(ET-1),肿瘤坏死因子-α(TNF-α)、透明质酸(HA)、Ⅳ型胶原(Ⅳ·C)含量变化,并探讨其与食管静脉曲张的关系.方法采用放免法分组检测60例肝硬化患者及20例正常人ET-1、TNF-α、Ⅳ*C和HA水平.结果肝硬化组ET-1、TNF-α、HA和Ⅳ*C含量均高于正常对照组(P<0.05~0.01),肝硬化Child C级均高于Child B级和Child A级,Child分级与ET-1、TNF-α、HA和Ⅳ·C含量呈正相关(r=0.64,r=0.57,r=0.69;P<0.05);食管静脉曲张患者ET-1、TNF-α、HA和Ⅳ*C含量均高于无食管静脉曲张者,并随食管静脉曲张严重程度而上升.结论肝硬化患者ET-1、TNF-α、HA和Ⅳ*C含量检测对了解肝硬化程度有帮助。

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目的 比较肝硬化患者血浆内皮素-1(ET-1),肿瘤坏死因子-α(TNF-α)、透明质酸(HA)、Ⅳ型胶原(Ⅳ·C)含量变化,并探讨其与食管静脉曲张的关系.方法采用放免法分组检测60例肝硬化患者及20例正常人ET-1、TNF-α、Ⅳ*C和HA水平.结果肝硬化组ET-1、TNF-α、HA和Ⅳ*C含量均高于正常对照组(P<0.05~0.01),肝硬化Child C级均高于Child B级和Child A级,Child分级与ET-1、TNF-α、HA和Ⅳ·C含量呈正相关(r=0.64,r=0.57,r=0.69;P<0.05);食管静脉曲张患者ET-1、TNF-α、HA和Ⅳ*C含量均高于无食管静脉曲张者,并随食管静脉曲张严重程度而上升.结论肝硬化患者ET-1、TNF-α、HA和Ⅳ*C含量检测对了解肝硬化程度有帮助。

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Available abstract

目的 比较肝硬化患者血浆内皮素-1(ET-1),肿瘤坏死因子-α(TNF-α)、透明质酸(HA)、Ⅳ型胶原(Ⅳ·C)含量变化,并探讨其与食管静脉曲张的关系.方法采用放免法分组检测60例肝硬化患者及20例正常人ET-1、TNF-α、Ⅳ*C和HA水平.结果肝硬化组ET-1、TNF-α、HA和Ⅳ*C含量均高于正常对照组(P<0.05~0.01),肝硬化Child C级均高于Child B级和Child A级,Child分级与ET-1、TNF-α、HA和Ⅳ·C含量呈正相关(r=0.64,r=0.57,r=0.69;P<0.05);食管静脉曲张患者ET-1、TNF-α、HA和Ⅳ*C含量均高于无食管静脉曲张者,并随食管静脉曲张严重程度而上升.结论肝硬化患者ET-1、TNF-α、HA和Ⅳ*C含量检测对了解肝硬化程度有帮助。

Key concepts: Medicine, Hyaluronic acid, Tumor necrosis factor alpha, Necrosis, Tumor necrosis factor α, Pathology, Internal medicine, Anatomy

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Comparison of contents of the endothelin -1,tumor necrosis factor-α,hyaluronic aid and collagen type IV in patient with hepatocirrhosis — Research Paper | ScholarLens