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The changes of Endothelin-1 and tumor necrosis factor-α in the congestive heart failure and the intervention role of vitamin E and vitamin C

王矩伟, 邹秋萍, 陈春波, 张金英, 党波, 赵云

Abstract

目的探讨充血性心力衰竭(CHF)患者肿瘤坏死因子(TNF-α)、内皮素-1(ET-1)的变化及维生素E、C的干预作用.方法将65例心力衰竭患者随机分为两组:A组32例,给予强心、利尿、扩血管治疗;B组33例,在A组治疗药物的基础上加维生素E 200 mg,1次/d,维生素C 200 mg,3次/d,共2周;采用特异性放免法和双抗体夹心ELTSA法分别检测65例心力衰竭患者及32例健康者血TNF-α和ET-1浓度.结果①充血性心力衰竭患者TNF-α和ET-1水平显著高于对照组(P＜0.01);②两组患者治疗后心功能恢复一个级别以上,B组ET-1和TNF-α水平较A组显著下降(P＜0.05).结论 ET-1,TNF-α参与心力衰竭的发生发展的病理生理过程,维生素E、C可降低心力衰竭患者ET-1,TNF-α水平.

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Key concepts: Heart failure, Medicine, Vitamin, Tumor necrosis factor α, Intervention (counseling), Internal medicine, Tumor necrosis factor alpha, Vitamin D and neurology