2002•中国医师杂志Requires access

A Study on the Relationship Between Serum Levels of Hyaluronic Acid,Type IV Collagen,Laminin and Hepatic Fibrosis in Patients with Chronic Hepatitis B

王晓春, 刘立鹏, 龙苏, 周毅刚, 徐绍锐, 罗向波, 黄顺玲

Abstract

目的研究血清肝纤维化指标透明质酸(HA)、Ⅳ型胶原(ⅣC)及层粘蛋白(LN)与慢性乙型肝炎肝纤维化的关系.方法对252例慢性乙型肝炎患者用放射免疫法检测血清HA、ⅣC、LN水平及定量PCR检测血清HBV-DNA.结果血清HA、ⅣC、LN水平与慢性肝炎发展呈正相关,且在慢性重度肝炎及肝硬化阶段处于最高水平(P＜0.01).结论血清HA、ⅣC、LN水平可不同程度反映肝纤维化程度,可作为肝纤维化血清检测指标.

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Key concepts: Hyaluronic acid, Laminin, Fibrosis, Hepatic fibrosis, Chronic hepatitis, Medicine, Type IV collagen, Hepatitis