Clinical Effect of edaravone on serum superoxide dismutase and malondialdehyde levels in elderly transient ischemic attack

Objective To investigate the clinical effect of Edaravone on transient ischemic attack and serum superoxide dismutase and malondialdehyde levels in the elderly. Methods Ninety eight cases with transient ischemic attack treated in our hospital were chosen as the objects, which were randomly divided into observation group and control group (n=49 for each). Patients in observation group were treated with Edaravone combined with conventional therapy, and patients in control group were treated with conventional therapy. The clinical effect and levels of SOD and MDA were analyzed and compared between the two groups. Results The effective rate and total efficiency were higher in observation group than in control group (79.6% vs. 55.1%, 95.9% vs. 83.7%, χ2=6.914 and 4.354, P=0.008 and 0.032). The SOD level was higher and the MDA level was lower in observation group than in control group (both P<0.001) after treatment. Conclusions Edaravone could improve the symptoms of transient ischemic attack in the elderly, and increase the activity of SOD and reduce MDA level, which is helpful to reduce lipid peroxides, alleviate free radical toxicity, and improve the anti-oxidation ability. Key words: Ischemic attack, transient; Free radical scavengers; Superoxide dismutase; Malondialdehyde