The influence on free radicals and correlation with serum ferritin after therapy with edaravone in acute cerebral infarction

Objective To observe the changes of serum ferritin(SF),MDA and SOD in the patients with acute cerebral infarction(ACI) and recovery of these changes after therapy with edaravone.Method Sixty-eight patients with ACI were divided into two treatment groups i.e.ederavone treatment group(30 cases) and conventional treatment group(38 cases),at random.SF,MDA and SOD were determined in these patients,China Stroke Scale(CSS scale)was used to evaluate the extent of neurological defect and the ischemic volume of ACI was calculated by CT scan or MRI.Results SF level was higher in ACI group than in healthy control group.The increase in level of SF was slower in edaravone therapy group than in conventional therapy group.SF level was positively correlated with the MDA level and negatively correlated with the SOD level.The MDA level was also negatively correlated with the SOD level. Conclusions SF may play a role in the pathophysiological events during the acute phase of ACI.Edaravone therapy can raise the level of SOD,reduce the level of MDA and control the level of SF in acute phase of ACI by scavenging free radicals.