Effects of recombinant human epidermal growth factor on wound healing of perianal absceess after operation

Objective To evaluate the clinical effects of recombinant human epidermal growth factor (rhEGF) on wound healing of perianal absceess after operation. Methods 80 patients who received operation of perianal absceess were selected.The patients were randomly divided into the study group(n=40) and control group(n=40). All the patients underwent the treatment of anal abscess incision and drainage.The patients in the control group were disinfected routinely and treated by metronidazole, while the patients in the study group were treated by rhEGF after disinfection of saline.All patients were followed up for one month after surgery.The wound edema score, granulation growth and the healing time of the wound were recorded. Results One month after surgery, the wound edema score in the study group was less than that in the control group at any time.After 2 weeks and 4 weeks, the wound edema scores in the study group were (1.41±0.33)points, (0.54±0.11)points, which were significantly lower than (2.09±0.28)points, (1.37±0.16)points in the control group (t=9.937, 27.036, all P<0.001). After 2 weeks and 4 weeks, the granulation growth scores in the study group were (1.71±0.38)points, (0.81±0.16)points, which were significantly lower than (2.16±0.38)points, (1.66±0.21)points in the control group (t=5.296, 20.363, P<0.001). The healing time of the wound in the study group was (19.52±1.47)d, which was less than (25.49±1.75)d in the control group (t=16.521, P<0.05). Conclusion The rhEGF can distinctly promote wound healing and shorten the healing time of perianal absceess after operation, which is worthy of the clinical promotion. Key words: Perianal absceess; Recombinant human epidermal growth factor; Wound edema; Granulation growth