2014•Chin J Postgrad MedRequires access
Clinical significance of serum hyaluronic acid,procollagen type III, collagen type IV and laminin in patients with chronic renal failure
陈峻, 赵岚, 王松姣
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Abstract
Objective To investigate the chronic renal failure (CRF) patients with serum hyaluronic acid (HA),procollagen type Ⅲ (PC-Ⅲ),collagen type Ⅳ (C-Ⅳ) and laminin (LN) joint detection of clinical significance.Methods Using chemiluminescence method in 80 cases of CRF patients (CRF group) and 60 healthy (control group) serum HA,PC-Ⅲ,C-Ⅳ and LN for joint detection and comparison.Results The serum HA,PC-Ⅲ,C-Ⅳ in CRF group was significantly higher than that in control group [(305.37 ± 41.28) μ g/L vs.(73.26 ± 21.21) μ g/L,(236.39 ± 56.63) μ g/L vs.(68.46 ± 32.55) μtg/L,(112.54 ±26.73) μg/L vs.(55.36 ± 18.44) μg/L] (P ＜0.01).The LN there was no statistically significant difference between two groups (P ＞ 0.05).Conclusion Detecting HA,PC-Ⅲ,C-Ⅳ for the early diagnosis and therapeutic efficacy observation of patients with CRF has important clinical significance.
Key words:
Kidney failure,chronic; Hyaluronic acid; Collagen; Laminin