2004•Journal of Yanan UniversityRequires access

The Diagnostic Value of Serum HA,PC III、IV-C、and LN for Hep atofibrosis

Shi Yan-dong

Abstract

To evaluate the diagnostic value of serum hyaluronic acid(HA),type Ⅲ procollagen(PC Ⅲ),typeⅣ collagen(Ⅳ- C)and laminin(LN)for hepatofibrosis,these 4 serum components were measured by RIAin180 cases with chronic ilver disease.The serum levels of HA ,PC Ⅲ,Ⅳ-C and LN in chronic hepatitis and cir-rhosis patients were significantly higher than those in the control group(P0.05)and increased with the de-velopment of hepatitis and fibrosis.These items Could reflect the degree of hepatic fibrosis and might be the indicators of hepatic cirrhoses in early stage.

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Key concepts: Procollagen peptidase, Hyaluronic acid, Laminin, Hepatic fibrosis, Gastroenterology, Internal medicine, Type IV collagen, Chronic hepatitis