Clinical study of benazepril combined with amlodipine in the treatment of essential hypertension

Objective To investigate the clinical efficacy of benazepril combined with amlodipine in the treatment of essential hypertension. Methods From January 2016 to January 2017, 90 patients with coronary heart disease in Taizhou Central Hospital were selected in the study, and they were randomly divided into three groups, with 30 cases in each group.The observation group(A group) was treated with benazepril combined with amlodipine, the control group (B group ) was treated with benazepril, and the control group (C group) was treated with amlodipine.The clinical efficacy, blood pressure, blood lipid changes, blood glucose changes before and after treatment in the three groups were compared. Results The total effective rate of A group was 96.367%, which of B group was 66.67%, which of C group was 70.00%, and the clinical efficacy among the three groups had statistically significant difference(χ2=11.96, P 0.05). After treatment, the SBP, DBP of the three groups were significantly lower than those before treatment(t=5.68, 7.21, 3.52, 3.16, 3.64, 3.16, all P 0.05). After treatment, only the FPG, FINS of A group had statistically significant differences compared with those before treatment(t=5.14, 3.65, all P 0.05). Conclusion Benazepril combined with amlodipine in the treatment of essential hypertension is effective, safe, and has less adverse reactions. Key words: Hypertension; Comparative effectiveness research; Benazepril; Amlodipine