Analysis of the Clinical Efficacy of Benazepril plus Amlodipine in the Treatment of Hypertension

Objective: To investigate the efficiency and safety of benazepril plus amlodipine in the clinical treatment of hypertension. Methods: 90 patients with hypertension were randomly divided into the control group 1(n=30) which was treated by benazepril alone, the control group 2(n=30) which was treated by amlodipine alone as well as the observation group(n=30) which was treated by benazepril and amlodipine for 12 weaks. The systolic blood pressure, diastolic blood pressure, serum total cholesterol, triglyceride, and high density lipoprotein cholesterol were detected and compared before treatment and 12 weeks after treatment. Results: After treatment, the total effective rate of observation group was 93.3%, which was significantly higher than those the control group 1(63.3%) and the control group 2(56.7%)(P0.05). The degree of blood pressure reduction of observation group was more significant compared with the control group 1 and controlgroup 2(P0.05), while there was no significant difference between the control group 1 and control group 2(P0.05).The improvement of TC, TG and HDL-C of observation group were obviously better than those of the control group 1 and control group2(P0.05). The incidence rate of adverse reactions was 6.7% in the observation group, which was significantly lower than those of the control group 1(26.7%) and the control group 2(23.3%)(P0.05). Conclusions: The efficacy and safety of benazepril combined with amlodipine were evidently better than benazepril or amlodipine alone in the treatment of hypertension, which was worthy of clinical popularization.