Relationship and expression of survivin and p53 in colorectal carcinoma

Objective To investgate the expression of survivin and p53 and to evaluate their relationship in colorectal carcinoma.Methods The expression of survivin and p53 were evaluted using immunohistochemistry in 58 cases of colorectal carcinoma tissue,25 cKses of paracarcinoma tissue and 39 cases of normal colonia membrance tissue.Results The positive rates of survivin and p53 in colorectal carcinoma were 72.4%(4:2/58)and 63.8%(37/58).The positive rates of survivin and p53 in colorectal carcinoma were significantly higher than paracarcinoma tissue and normal colonia membrance tissue(P＜0.05).Survivin and p53 expression were related to metastasis of colorectal carcinoma(P＜0.05).The expression of survivin was obviously correlated with p53 in colorectal carcinoma(r=0.291,P=0.020).Conclusion Overexpreasion of survivin may play a crucial role in the origin and development of colorectal carcinoma. Key words: Coloric neoplasms; Inhibitor of apoptosis proteins; Tumor suppressor protein p53